OVERVIEW

Purpose: Detecting and confirming drug abuse involving mitragynine.

CLINICAL INFORMATION

Mitragynine, an alkaloid, is prominently present in the Kratom plant indigenous to Asia. The leaves of this plant are ingested for their stimulant and analgesic properties, with these effects primarily attributed to the presence of mitragynine. Notably, extracts derived from the Kratom plant are marketed for their potential medicinal benefits, albeit with the recognition of their potential for misuse. It's noteworthy that certain Kratom products have been reported to contain O-desmethyltramadol, which is believed to originate from external sources.

SPECIMEN COLLECTION

Specimen Type: Random urine
Preferred Collection Container: Non-sterile specimen container
Specimen Required: 3 mL urine; minimum 1 mL

TEST DETAILS

Methodology: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Compliance Category: Laboratory Developed Test (LDT)
This test was developed and assessed by DMD in compliance with CLIA requirements for its analytical performance characteristics and clinical application. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Reference Interval: Negative
Drug/Metabolite Tested:
Drug/Metabolite Cutoff concentration (to be confirmed by our assay)
Mitragynine (Kratom) 4 ng/mL
CPT code(s): 80323
Turnaround Time: 90% < 48 hours, 50% < 24 hours

SPECIMEN PROCESSING

Transport Temperature: Refrigerated (preferred) or room temperature overnight shipping.
Specimen Stability: 3 days at room temperature and 14 days at refrigerated and frozen temperatures (to be further confirmed with our validation).
Rejection Criteria: Stability limits exceeded.

Director: Cheryl Hanau, MD; Donald Hall Jr., PhD; Garth Ehrlich, PhD; Yinghua Qiu, PhD, DABCC

Review Date: 08/28/2023

Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

The information on these pages is provided for general information only and should not be used for diagnosis or treatment, or as a substitute for consultation with a physician or health care professional. If you have specific questions or concerns about your health, you should consult your health care professional.

 
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