Benefits of the Pan-Domain Assay from Drexel Medicine Diagnostics

Tick-borne infections are often polymicrobial and contain pathogens from multiple kingdoms. Drexel Medicine Diagnostics has developed two companion assays that together provide near universal coverage for all non-viral pathogens – the Pan-Domain Assay.

The Pan-Domain Assay - Advantages*

Broad coverage:
The assays are based on the highly conserved 16S and 18S ribosomal RNA genes of bacteria and eukaryotes, respectively. They can be ordered individually or together as a single comprehensive assay. Together they provide for unbiased coverage of bacteria, fungi and single-celled eukaryotic pathogens which allows for:

• Identification of multiple pathogens simultaneously from individual specimens, providing for characterization of mixed or polymicrobial infections without having to specify what to test for, thus even unsuspected pathogens will be identified.
• Complete species-specific microbiome analyses of complex specimens including mucosal, fecal, periodontal, salivary, surgical, veterinary, wound, etc.

Highly sensitive:
The assays are based on the polymerase chain reaction which provides for billion-fold amplification of target DNAs.

Highly specific:
Long PCR and long-read DNA sequencing provide the information to be able to identify pathogens to the species level (in some cases even the strain level).

Highly quantitative:
Nearly linear over 1000-fold differences in input DNA to detect low copy number pathogens and also the relative percentages of multiple pathogens in complex specimen types — providing the information for tailoring therapy.

*These statements have not been evaluated by the FDA. The assays described here are currently undergoing rigorous validation testing and are not yet available. This is for informational purposes only and is not an advertisement of services.

The information on these pages is provided for general information only and should not be used for diagnosis or treatment, or as a substitute for consultation with a physician or health care professional. If you have specific questions or concerns about your health, you should consult your health care professional.

The images being used are for illustrative purposes only; any person depicted is a model.

 
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