If you are HIV-negative and have had a definite or possible exposure to HIV, you may be able to use post-exposure prophylaxis (PEP) to prevent HIV infection. PEP is a pill and must be taken within 72 hours (3 days) of HIV exposure.

Once you take your first dose, you will continue to take a PEP pill at the same time every day, for 28 days. While you are taking PEP, always use a condom or other barrier method with sexual partners and avoid sharing needles or syringes.

PEP is meant to be used in emergency situations of one-time HIV exposure. Pre-exposure prophylaxis (PrEP) may be a better prevention method if you are frequently exposed to HIV or at ongoing risk.

PEP may be right for you if you are HIV-negative or don’t know your HIV status, and you think you may have been exposed to HIV in the last 72 hours (3 days):

• During sex (for example, you had a condom break with a partner of unknown HIV status or a partner with HIV who is not virally suppressed)
• Through shared needles, syringes, or other equipment used to inject drugs (for example, cookers)
• Through sexual assault
• Through a possible workplace exposure, such as from needlestick injury. Workplace HIV transmission is very rare.

PEP is an important part of ending the HIV epidemic because it helps reduce the transmission of HIV after exposure. When you talk to a doctor about PEP, you’ll have a chance to discuss whether some of the other HIV prevention methods below will also work for you.

**“Sex” can mean different things to different people. Here, we mean oral, anal or vaginal sex, or other sexual activity where bodily fluids are exchanged.

The information on these pages is provided for general information only and should not be used for diagnosis or treatment, or as a substitute for consultation with a physician or health care professional. If you have specific questions or concerns about your health, you should consult your health care professional.

The images being used are for illustrative purposes only; any person depicted is a model.

 
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